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Vitamin D


Hormone-D





There is more research on the benefits of Vitamin D3 for human health than ANY OTHER vitamin or mineral...the evidence is CLEAR, the higher your Vitamin D3 levels are, the better chance of a longer, healthier life, free of the FLU, cancer, heart disease, strokes, etc..
There are HUNDREDS of studies showing the connection of insufficient or deficient 25-hydroxyvitamin D blood levels with higher risks of cancer, vascular disease, and chronic inflammation (underlying cause of ALL disease) 
                                       -Dr. Charles Majors

Why?

  • Necessary component of the immune system.
    • Low levels= increase risk for:
      • Flu  (2x more likely)
      • Those who supplemented with Vit D had a 9x lower chance of flu during the winter
      • Respiratory infections
      • Autoimmune
      • DNA repair and metabolic processes
    • 42-50-80% of adults (probably more!) are deficient
    • 70% of kids 6-11 deficient (avg child now only get 4 min of outdoor playtime! And 25% of schools have ditched recess.)  
    • Associated with 50% increased risk of heart attack in those deficient, and could prevent 50% of breast cancer cases
    • “At present, the US cancer mortality rate is equivalent to eight to 10 airplanes crashing each and every single day. Optimizing vitamin D rates across the general population could reduce that by about 50 percent.” -Dr. Mercola
  • You have ~25,000 genes within your genome.  Vit D affects ~3,000 of these.  
  • Vit D receptors on cells throughout your body. 
  • Adequate levels shown to positively affect 16 different types of cancer
    • Potentially reducing your risk of cancer by 60%
How?
  • Respiratory tract
    • Modified form of Vit D binds to specialized receptors, resulting in reduced inflammation.
    • Aids in production of Cathelicidins.  These are antimicrobial/antiviral proteins that aid in the destruction of invaders
  • Getting a little heady…
    • Macrophages are needed by our body to carry out many different immune system processes.
      • The vitamin D3-binding protein (Gc protein)-derived macrophage activating factor (GcMAF) activates tumoricidal macrophages against a variety of cancers indiscriminately.
      • "The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5a for neutrophils in inflammactivation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF))"
        • EXTREMELY powerful cancer killing component!
    • Technical name (circulating form): 25-hydroxyvitamin D.  Actually a steroidal type compound rather than a vitamin.  (active form: 1,25-dihydroxyvitamin D)

Vitamin D controls T cell antigen receptor signaling and activation of human T cells
Got it! Now how much do I need?
  • Every individual will vary.  Depending on your latitude, exposure to sun (need ample amount of skin exposed!), diet, age, pregnancy, current levels of circulating Vit D, etc.
  • YES. Get out in the sun and enjoy it! Having your body produce it’s own Vit D is exactly what it is meant to do!  Taking into consideration your location, time of year, time of day, and skin tone; stay in the sun HALF the amount of time it would take to get a slight burn.  Take a break, and go back out.  In order to synthesize enough Vit D, expose your arms, legs, and part/all of your trunk.  No need to bust out the speedo, but exposing more surface area is critical in producing optimal Vit D.  
  • Getting your Vit D levels checked is Ideal..  especially if you suffer from a chronic condition, of any kind.  Levels between 50 and 80 ng//ml is ideal.  
  • ⅔ of the US population is deficient in Vit D (probably more!)    Deficiency=30ng/ml
Make sure its HIGH QUALITY without any added junk! It defeats the purpose if you go cheap or don’t get the right products.  
MyEssentials is a resource to not only get the right amount of high quality Vit. D, but to see what else you may need as well.



http://burl.co/5F60F17
Vitamin D deficiency is independently associated with mortality among critically ill patients. Clinics (Sao Paulo). 2015;70(5):326-32.
Scientific documentation of the relationship of vitamin D deficiency and the development of cancer. J Environ Pathol Toxicol Oncol. 2009;28(2):133-41.
Anti-inflammatory effect of 1alpha,25-dihydroxyvitamin D(3) in human coronary arterial endothelial cells: Implication for the treatment of Kawasaki disease. J Steroid Biochem Mol Biol. 2009;113(1-2):134-8.
http://articles.mercola.com/sites/articles/archive/2013/12/22/dr-holick-vitamin-d-benefits.aspx


Great info here:  
https://www.westonaprice.org/health-topics/abcs-of-nutrition/update-on-vitamins-a-and-d/

Low Cloud Cover-Adjusted Ultraviolet B Irradiance Is Associated with High Incidence Rates of Leukemia: Study of 172 Countries.
http://www.ncbi.nlm.nih.gov/pubmed/26637119


http://articles.mercola.com/sites/articles/archive/2013/12/22/dr-holick-vitamin-d-benefits.aspx

For kiddos
http://www.ncbi.nlm.nih.gov/m/pubmed/26763046/

Motherload:
http://www.mercola.com/article/vitamin-d-references.htm


 2016 Oct 14;8(1):e1248324. eCollection 2016 Jan-Dec.

Estimated economic benefit of increasing 25-hydroxyvitamin D concentrations of Canadians to or above 100 nmol/L.

  • https://www.ncbi.nlm.nih.gov/pubmed/27942348
  •  "The diseases affected by 25(OH)D concentration included cancer, cardiovascular disease, dementia, diabetes mellitus, multiple sclerosis, respiratory infections, and musculoskeletal disorders. We used 25(OH)D concentration-health outcome relations for breast cancer and cardiovascular disease and results of clinical trials with vitamin D for respiratory infections and musculoskeletal disorders to estimate the reductions in disease burden for increased 25(OH)D concentrations. If all Canadians attained 25(OH)D concentrations>100 nmol/L, the calculated reduction in annual economic burden of disease was $12.5 ± 6 billion on the basis of economic burdens for 2016 and a reduction in annual premature deaths by 23,000 (11,000-34,000) on the basis of rates for 2011. "
  • Important to note:  You MUST address all other essentials of health to remain healthy!! "However, the effects on disease incidence, economic burden, and mortality rate would be phased in gradually over several years primarily because once a chronic disease is established, vitamin D affects its progression only modestly."


Flu Vaccines aren't effective...but you know what is?
Vitamin D3!
...
Just look how Vitamin D3 can prevent the flu, increase longevity, reverse Cancer, stop disease, colds and infections...
*Research has demonstrated that vitamin D blood levels in the range of 50 to 80 ng/mL are associated with reduced mortality and a lower risk of common diseases. (colds, flu's, infections, etc)
*Another study in 2015 entailing 135 ICU patients revealed a 32.2% risk of mortality when vitamin D levels were below 12 ng/mL.....
compared to a 13.2% risk of mortality if levels were greater. This finding shows that vitamin D deficient patients die at a 2.4-fold greater rate. (1)
*There are HUNDREDS of studies showing the connection of insufficient or deficient 25-hydroxyvitamin D blood levels with higher risks of cancer (2), vascular disease, and chronic inflammation (underlying cause of ALL disease)
(3)
There is more research on the benefits of Vitamin D3 for human health than ANY OTHER vitamin or mineral...the evidence is CLEAR, the higher your Vitamin D3 levels are, the better chance of a longer, healthier life, free of the FLU, cancer, heart disease, strokes, etc...
You and your children should have a Vitamin D3 level between 60-80ng. The majority of EVERY patient I check (even some taking D3) is between 10-30ng.
(1) Vitamin D deficiency is independently associated with mortality among critically ill patients. Clinics (Sao Paulo). 2015;70(5):326-32.
(2) Scientific documentation of the relationship of vitamin D deficiency and the development of cancer. J Environ Pathol Toxicol Oncol. 2009;28(2):133-41.
(3) Anti-inflammatory effect of 1alpha,25-dihydroxyvitamin D(3) in human coronary arterial endothelial cells: Implication for the treatment of Kawasaki disease. J Steroid Biochem Mol Biol. 2009;113(1-2):134-8.

~~Dr. Charles Majors



FOR YOUR BRAIN

Vitamin D Deficiency a Brain Disruptor

Vitamin D deficiency disrupts structural brain connectivity and harms learning and memory by destabilizing perineuronal nets (PNNs) that provide scaffolding for neurons, new research suggests.
PNNs are made of proteins and sugar molecules that form a strong, supportive mesh around certain neurons. In so doing, they stabilize the contacts these cells make with other neurons.
Thomas Burne, PhD, and colleagues from the University of Queensland, Brisbane, Australia, removed vitamin D from the diet of a group of healthy young adult mice, while a control group continued to receive vitamin D.
After 20 weeks, the vitamin D–deficient group showed a significant decline in the ability to remember and learn, compared with the control group.
 
The brains of the vitamin D–deficient mice showed a pronounced reduction in PNNs in the hippocampus, a brain region crucial to memory and learning. There was also a pronounced reduction in both the number and strength of connections between neurons in the hippocampus. Vitamin D deficiency had no apparent impact on hippocampal volume.
The study was published online February 2, 2019 in Brain Structure and Function.

Bad Connection

"Intriguingly, the right side of the hippocampus was more affected by vitamin D deficiency than the left side," Burne said in a news release.
Loss of function in this area may contribute to severe memory deficits and a distorted perception of reality, hallmarks of schizophrenia, he noted. About 70% of people with schizophrenia have insufficient vitamin D, and schizophrenia patients also tend to have more disruption in the right side of their hippocampus, he added.
In a second paper, published online February 19, 2019 in Trends in Neuroscience, Burne and colleagues propose that adequate (normal) vitamin D levels prevent certain enzymes from breaking down PNNs, but when vitamin D levels drop, these enzymes become unchecked and begin to degrade PNNs.
"As neurons in the hippocampus lose their supportive perineuronal nets, they may have trouble maintaining connections, and this ultimately leads to a loss of cognitive function," said Burne.
The new findings support "converging evidence" from human and animal studies that show an association between vitamin D deficiency and cognitive impairment, the researchers conclude.
 
This research was supported by the National Health and Medical Research Council and a University of Queensland International PhD Scholarship to one of the investigators. The authors have disclosed no relevant financial relationships. 
 
Sources:
Brain Struct Funct. Published online February 2, 2019. "Adult vitamin D deficiency disrupts hippocampal-dependent learning and structural brain connectivity in BALB/c mice” 
 
Trends Neurosci. Published online February 19, 2019. "Vitamin D in Synaptic Plasticity, Cognitive Function, and Neuropsychiatric Illness"


Now for a little fun


  • Macrophages are needed by our body to carry out many different immune system processes. 
    • The vitamin D3-binding protein (Gc protein)-derived macrophage activating factor (GcMAF) activates tumoricidal macrophages against a variety of cancers indiscriminately.
    "The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5a for neutrophils in inflammactivation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF))"

  • Vit D binding protein.   Macrophage activating factor.
    • Extremely powerful cancer cell destroyer
    • GC protein needs to be converted to GcMAF protein for biological activity in destroying cancer and carrying out other immune system functions.

    • Inhibitor of this process: Enzyme called nagalase: produced by cancer cells and viruses. 
      • Cause immunodeficiency and linked to autism. 
      • Introduced through vaccinations? 
        • Found in high concentrations in autistic children, when not found at these levels at birth. 
        • Nagalase binds to T and B lymphocytes and inhibits their activity. Leading to immunocomprimise and significantly increasing the ability for cancer to develop. 
        • Viruses may be able to attach to Nagalase, thereby being able to enter the cell with less immune response.  
        • Macrophages require Vit D, absence or reduced amounts, inflammatory reactions from the macrophages occur. Increased release of cytokines, which leads to chronic inflammation, reduced insulin sensitivity (which is why there are studies that have shown the connection between decreased levels of Vit D and type II diabetes).  
        • Also increases inflammation in the cardiovascular system.  Atherosclerosis and plaguing.  
    • With angiogenesis: (Needed for tumor growth and sustainability) 


https://www.researchgate.net/publication/233539719_Role_of_vitamin_D_on_cancer_immunotherapy
http://www.ncbi.nlm.nih.gov/pubmed/24783350



Dr. James Chestnut



Relation to Nervous system health

Vitamin D Levels Predict Multiple Sclerosis Progression

https://www.nih.gov/news-events/nih-research-matters/vitamin-d-levels-predict-multiple-sclerosis-progression

http://articles.mercola.com/sites/articles/archive/2014/11/17/vitamin-d-deficiency-asthma-multiple-sclerosis.aspx

Sunscreen 



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