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Why take care of yer GUT?

Ultimate Food-Brain Connection Guide
http://www.greenmedinfo.com/guide/health-guide-food-brain-connection

http://www.greenmedinfo.com/blog/probiotics-change-brain-activity-emotional-response

http://snip.ly/DTZ9#http://www.mindbodygreen.com/0-14119/10-things-you-need-to-know-about-your-microbiome.html

https://drjockers.com/10-ways-improve-gut-microbiome/

https://drjockers.com/top-33-prebiotic-foods/

http://www.greenmedinfo.com/blog/tale-two-brains-how-your-second-brain-key-understanding-many-chronic-illnesses

http://www.collective-evolution.com/2014/10/26/the-brain-gut-connection-for-mental-well-being/

http://www.collective-evolution.com/2014/11/09/the-secret-killer-how-its-affecting-every-aspect-of-your-health-how-to-reverse-it/

http://www.npr.org/blogs/health/2014/12/12/350591892/poo-and-you-a-journey-into-the-guts-of-a-microbiome

http://eatlocalgrown.com/article/11752-candida-overgrowth.html?c=tca







Affects of the western diet




http://articles.mercola.com/sites/articles/archive/2014/12/27/seeding-baby-microbiome.aspx

http://drjockers.com/2015/02/healthy-people-destroying-digestive-systems/

http://eatlocalgrown.com/article/14696-leaky-gut-chronic-inflammation.html?c=NSM

http://www.realwayoflife.com/en/2015/09/04/two-pounds-of-bacteria-in-our-body-can-adjust-our-mood-connections-between-intestine-and-brain/

  • Two pounds of bacteria can alter our mood, and influence much of our overall health. 
Microbiome
Ubiome
https://ubiome.com/blog/

Using antibiotics


Gut bacteria shaking up cancer research
http://www.bloomberg.com/news/articles/2016-03-14/how-gut-bacteria-are-shaking-up-cancer-research

The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection.

https://chriskresser.com/is-it-the-terrible-twos-or-is-it-a-disrupted-gut-microbiome/

Heal Your Gut, Heal Your Brain

  • 'In the first few years of life, an estimated 700 to 1,000 new synapses (connections between neurons) form every second"
    • Probably a good idea to have a healthy, optimally functioning gut and nervous system, with properly controlled systemic inflammation. 

Intestinal Bacteria Alter Gut and Brain Function

NEUROSCIENCE NEWS
  • "The authors conclude that their findings raise the possibility that “microbiota-directed therapies, including pre- or probiotic treatment, may be beneficial in treating not only intestinal symptoms but also components of the behavioural manifestations of IBS.”
  • "Interestingly, the authors noted that since the study showed that microbiota in the gut can influence the brain, it “adds to evidence suggesting that the intestinal microbiota may play some role in the spectrum of brain disorders ranging from mood or anxiety to other problems that may include autism, Parkinson’s disease and multiple sclerosis.” However, they added that further work is required to better define the relationship in these conditions.""
  • http://neurosciencenews.com/microbiota-gut-brain-6183/


Nerves Control The Body’s Bacterial Community



  • "Using this model organism, the researchers from Kiel University addressed the question of how messenger substances produced by the nervous system, known as neuropeptides, control the cooperation and communication between host and microbes. They collected cellular, molecular and genetic evidence to show that neuropeptides have antibacterial activity which affects both the composition and the spatial distribution of the colonizing microbes."
  • "In order to reveal the connections between neuropeptides and bacterial communities, the Kiel-based researchers first concentrated on the development of the freshwater polyp’s nervous system, from the egg stage through to an adult animal. Cnidarians develop a complete nervous system within about three weeks. During this developmental time, the bacterial communities covering the animal’s surface change radically, until a stable composition of the microbiome finally forms. Under the influence of the antimicrobial effect of the neuropeptides, the concentration of so-called Gram-positive bacteria, a subgroup of bacteria, decreases sharply over a period of roughly four weeks. At the end of the maturing process, a typical composition of the microbiome prevails, particularly dominated by Gram-negative Curvibacter bacteria. Since the neuropeptides are particularly produced in certain areas of the body only, they also control the spatial localisation of the bacteria along the body column. Thus, in the head region, for example, there is a strong concentration of antimicrobial peptides, resulting in six times fewer Curvibacter bacteria than on the tentacles."

  • "Based on these observations, the scientists concluded that throughout the course of evolution the nervous system also participated in a controlling role for the microbiome, in addition to its sensory and motor tasks. “The findings are also important in an evolutionary context. Since the ancestors of these animals have invented the nervous system, it seems that the interaction between the nervous system and the microbiome is an ancient feature of multicellular animals."

Host microbiota constantly control maturation and function of microglia in the CNS



 2003 Mar 28;278(13):11312-9. Epub 2002 Dec 19.

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.



 2015 Mar;45:118-27. doi: 10.1016/j.bbi.2014.10.018. Epub 2014 Nov 10.

Gut microbiome composition is associated with temperament during early childhood.






 2016 Jul 30;16(1):86. doi: 10.1186/s12876-016-0498-0.

The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review.


 2010 Jul;86 Suppl 1:13-5. doi: 10.1016/j.earlhumdev.2010.01.004. Epub 2010 Feb 4.

Mode of delivery affects the bacterial community in the newborn gut.

https://www.ncbi.nlm.nih.gov/pubmed/20133091
 2011 Dec;17(6):369-74. doi: 10.1016/j.anaerobe.2011.03.010. Epub 2011 Apr 16.

Immunology and probiotic impact of the newborn and young children intestinal microflora.




 2007 Sep;28(9):722-6. Epub 2007 Apr 13.

Effect of aspirin and ibuprofen on GI permeability during exercise.

  • During/post exercise is a particularly bad time to consume anything toxic, or that you do not want leaking from your gut.
  • Gut permeability increases after exercise, especially in the heat. 
  • Effects are especially heightened with asprin/NSAID use
    • "These results indicate that with prolonged running, gastroduodenal permeability is increased if aspirin or ibuprofen is used prior to such exercise. Furthermore, aspirin promotes greater gastroduodenal permeability and also increases small intestinal permeability."
 2016 Apr 28;3(2):240-251. eCollection 2016 Apr-Jun.

Heat stress, gastrointestinal permeability and interleukin-6 signaling - Implications for exercise performance and fatigue.

  • "During exertional heat stress, blood flow is preferentially distributed away from the intestinal area to supply the muscles and brain with oxygen. Consequently, the gastrointestinal barrier becomes increasingly permeable, resulting in the release of lipopolysaccharides (LPS, endotoxin) into the circulation"
  • Some other interesting stuff in here too.. 
 2008;53:61-73. doi: 10.1159/000151550.

Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: the 'canary in the coal mine' during exercise-heat stress?

"Reduced intestinal blood flow and high intestinal temperatures during exercise-heat stress can lead to intestinal barrier dysfunction. Such dysfunction may increase intestinal permeability to endotoxin. During exercise-heat stress, intestinal barrier dysfunction and endotoxemia can produce gastrointestinal symptoms and increased production of pro-inflammatory cytokines"




 2015 Mar;50(3):295-302. doi: 10.4085/1062-6050-49.5.04. Epub 2015 Jan 26.

Nonsteroidal anti-inflammatory drug use and endurance during running in male long-distance runners.

CONCLUSIONS:

Ibuprofen did not reduce the effect of muscle damage and pain on performance. Prophylactic use of nonsteroidal anti-inflammatory drugs did not have an ergogenic effect on running performance after exercise-induced muscle damage in male long-distance runners.





Look up Dr. Datis Kharazzian

Common Benefits of a High Probiotic Diet
             ~via Dr. Axe
  • Stronger immune system
  • Improved digestion
  • Increased energy from production of vitamin B12
  • Better breath because probiotics destroy candida
  • Healthier skin, since probiotics improve eczema and psoriasis
  • Reduced cold and flu
  • Healing from leaky gut and inflammatory bowel disease
  • Weight loss

http://draxe.com/probiotic-foods/
8 Probiotic Foods Infographic



Restore

https://revelationhealth.com/products/restore-for-gut-heath-32oz-bottle

From Restore: 

"HELPS MAINTAIN A HEALTHY IMMUNE SYSTEM
Restore is unlike any supplement on the market. Made in the US, Restore is a soil-derived, scientifically-backed mineral supplement that creates a firewall against toxins entering the gut wall. Restore helps create a biological environment for good gut bacteria to grow and flourish, to support improvement of overall health. To put it simply, Restore works.

Taking RESTORE before meals is preferred for maximum efficacy. Optimally 30 minutes before a meal because of Restore’s protective effects versus gluten and especially glyphosate, but you can take it immediately before, with a meal, or after a meal and still receive benefit. 
For the Hypersensitive Individuals: The more compromised or damaged the gut health of the individual, the more rapid and profound are the early results of the supplement. These clinical results are not the direct effects of the supplement, but instead reflect the innate healing process that occurs in a body as the firewall system is back up and running. For many, this is an improvement in mental clarity and sensory processing in as little as hours or days of first use. There is a subset of individuals, often with the most abnormal gut function/immune systems, and highest levels of inflammation, that can experience symptoms of tiredness, headache, bloating/increased gas, or gut membrane changes including greenish loose stool.In these cases there are often a few common factors present.
First, there is typically a history of mold exposure or bacterial overgrowth present. These can cause a change at the human cell DNA level at the site at which glutathione (the body’s most abundant antioxidant) is produced. As such, the individual cannot mount a normal antioxidant response that balances a healthy recovery of the immune system. In these situations, it is helpful to take a very slow and very gentle approach to tight junction and immune and brain health."


Charles Majors DC

"Anything that affects your GUT Always affects your Brain!"
From- brain cancer, seizures, Alzheimer's, ADHD, to depression, the health of your brain is DETERMINED by what is happening in your GUT!
Your gut is responsible for a WIDE VARIETY of functions in the body, over 80% of your immunity is in your gut, detoxification, inflammation, neurotransmitter and vitamin production and ANY ability to absorb nutrients relies on a HEALTHY GUT.
... But where do almost ALL doctors look at when someone is dx. with these conditions? Not the gut...
For example, when you're depressed, they will say, you don't have enough serotonin in your brain (the feel good chemical), so they give you VERY dangerous drugs to increase your ability to hold the small amount of serotonin you have in your brain. Where do you think almost ALL serotonin is made? IN THE GUT, this is why antidepressants only work for short periods of time.
Damage and inflammation in your gut, lead to a leaky gut and that leads to a leaky brain! These 2 tests are EXTREMELY important to run to get to the CAUSE(s) of why someone has brain cancer, depression, ADHD, etc. These are all symptoms that are secondary to a DAMAGED LEAKY GUT. Find the cause(s), the cause is the only cure!
*3 steps you can start NOW to protect your gut and heal your brain:
1. Increase your Probiotics (healthy bacteria)
-so eat more fermented foods, kefir and live-culture yogurt (as long as your testing shows no sensitivity)
-take a probiotic daily
2. Minimize your sugars/carbs/anything that turns to sugar. When you keep your blood sugar in balance, you will keep your gut bacteria in balance.
3. Stop damaging your gut by eliminating the main culprits:
-Sugar, Toxicity, Processed foods (bad fats, caffeine, alcohol, gluten, soy), dairy, NSAIDS will poke holes in your gut, high or low cortisol from stress, and birth control pills damage your gut.
These are just 3 of the many steps to maintain a healthy gut.
Better health through better chemistry isn't the answer. Better health through better living is.
(This is my quote from Dr. David Perlmutter M.D., who is the New York Times best selling author of Grain Brain and Brain Maker and the #1 doctor in the world on Gut Health)

health-benefits-of-kombucha-800x597


http://drjockers.com/2013/08/the-amazing-health-benefits-of-kombucha/



Some good ideas:

http://tasty-yummies.com/2016/04/17/digestion-101-a-north-to-south-process-part-5-the-large-intestine/

IgG dynamics of dietary antigens point to cerebrospinal fluid barrier or flow dysfunction in first-episode schizophrenia

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275312/





More Evidence Links Gut Bacteria to Dementia

HONOLULU —  Depletion of certain gut bacteria, and an elevated level of other bacteria, are associated with an increased risk for dementia, a new study suggests.
"Although our study has numerous limitations, the results suggest that the gut microbiome could be a new target for the management of dementia," study author Naoki Saji, MD, PhD, Vice Director, Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology in Japan, told Medscape Medical News.
Doctors should urge patients to "take care of their gut," said Saji.
The study was presented here at the International Stroke Conference (ISC) 2019, and published online January 30, 2019 in Scientific Reports.
The gut microbiome refers to microorganisms that live in the digestive tract; there are about a thousand different species of bacteria, comprising trillions of cells. Recent research has correlated certain changes in gut bacteria with inflammatory and autoimmune conditions, and studies have shown that changes in diet can alter gut bacteria.  
The gut microbiome has become a hot topic for many experts, including Saji. His research interests include associations between dementia and cerebrovascular and cardiovascular diseases. He supports the hypothesis that these diseases share common risk factors.
Results of previous research suggest a relationship between the gut microbiome and cardiovascular diseases. "I thought that a relationship between dementia and gut microbiome might be also possible," said Saji. 
The new study included 128 outpatients visiting a memory clinic at their institution; participants had a mean age of 74.2 years and 59% were female.
Researchers collected information on demographics, risk factors, and activities of daily living, and assessed cognitive function using neuropsychological tests and brain MRI scans.
As well, from fecal samples, they determined gut microbiota using terminal restriction fragment length polymorphism (T-RFLP) analysis. This, said Saji, is a well-established and reliable method of classifying gut microbiota.
Investigators divided study participants into demented and nondemented groups. They used multivariable logistic regression models to identify factors independently associated with dementia.
Silent lacunar infarcts and cerebral microbleeds were more frequently seen on MRI scans of patients with dementia, the researchers report.

Decreased Bacteroides

The T-RFLP analysis revealed group differences in components of gut microbiota. For example, levels of Bacteroides (enterotype I), which are organisms that normally live in the intestines and can be beneficial, were decreased in demented compared with nondemented patients.
Other bacteria (enterotype III) were increased in the group with dementia.
Multivariable analyses showed that enterotype I (odds ratio [OR] 0.1, 95% confidence interval [CI] 0.02 - 0.4, P < .001) and enterotype III (OR 12.7, 95% CI 3.3 - 65.8, P < .001) were strongly associated with dementia, independent of traditional dementia biomarkers such as APOE ε4 genetic status; deficits in certain neurochemicals; and high scores on Voxel-Based Specific Regional Analysis System for Alzheimer's Disease (VSRAD).
Fecal concentrations of ammonia, indole, skatole, and phenol were higher in demented compared with nondemented patients.
These new results indicate that dysregulation of the gut microbiome is independently and strongly associated with dementia, commented Saji.
The study had a number of limitations. One is that the cross-sectional design could not establish a causal relationship between differences in the gut microbiome and dementia. As it had relatively few patients, the study may have been at risk of being underpowered, and the absence of enterotype II among demented patients may have affected the statistical interpretation.
Another possible limitation is selection bias, as the study was performed in a single hospital-based cohort, and possible confounding factors, such as the release of inflammatory biomarkers, and nutritional and dietary parameters, were not assessed. 
Despite these drawbacks, Saji noted that the odds ratios in the study were high.
Saji suggested there may be common underlying mechanisms in the effects of gut microbial composition on multi-organ arteriosclerosis.
Analyses of the gut microbiome may not only lead to better ways to manage dementia, but perhaps to a new therapy for the disease.
Saji pointed to a recent report from Kobayashi et al suggesting that Bifidobacterium breve A1 supplementation may improve cognitive function in adults with mild cognitive impairment (MCI).
The 24-week, open-label, single-arm study examined the cognitive effects of the oral supplementation in 27 subjects, 19 of whom completed the study.
To assess cognitive function, the researchers used the Mini-Mental State Examination (MMSE) and Digit Symbol Substitution Test (DSST). They measured mental condition and quality of life for gastrointestinal symptoms using the Profile of Mood States 2nd Edition (POMS2), and the Gastrointestinal Symptom Rating Scale (GSRS).
The study found MMSE scores were significantly increased and GSRS scores significantly improved during the intervention.
Saji pointed to a recent report from Kobayashi et al suggesting that Bifidobacterium breve A1 supplementation may improve cognitive function in adults with mild cognitive impairment (MCI).
The 24-week, open-label, single-arm study examined the cognitive effects of the oral supplementation in 27 subjects, 19 of whom completed the study.
To assess cognitive function, the researchers used the Mini-Mental State Examination (MMSE) and Digit Symbol Substitution Test (DSST). They measured mental condition and quality of life for gastrointestinal symptoms using the Profile of Mood States 2nd Edition (POMS2), and the Gastrointestinal Symptom Rating Scale (GSRS).
The study found MMSE scores were significantly increased and GSRS scores significantly improved during the intervention.

Dietary Role?

Can diet alone boost beneficial gut bacteria enough to affect cognition? Some studies have suggested there may be such an advantage to the Mediterranean diet, which focuses on eating foods like fish, fruits, vegetables, nuts, and whole grains, and staying away from unhealthy fats and sugars, said Saji.
Iadecola noted, though, that it may not be this diet per se that affects cognitive function, but its lack of saturated fats.
The Alzheimer's Association International Conference (AAIC 2018) in Chicago last summer featured a number of studies that investigated how the digestive system, including gut and liver functions, may be related to changes in the brain, and to brain disorders such as dementia.
According to the Alzheimer's Association, scientists have reported that some species in the microbiome can promote protein build-up in the brain. This may be significant as accumulation of amyloid and tau proteins are hallmarks of Alzheimer's disease (AD).
And recent reports from experiments in AD mouse models suggest that changing the bacterial profile in the digestive tract, by changing their diet, may reduce amyloid plaques, lower inflammation, and improve memory.
The study was supported by the Research Funding of Longevity Sciences; NARO Bio-oriented Technology Research Advancement Institution project (Advanced integration research for agriculture and interdisciplinary fields); and the Toyoaki Scholarship Foundation. Saji reports grants from NARO Bio-oriented Technology Research Advancement Institution project, the BMS/Pfizer Japan Thrombosis Investigator Initiated Research Program, the Toyoaki Scholarship Foundation, the National Center for Geriatrics and Gerontology, and the Japan Agency for Medical Research and Development (AMED). Iadecola has disclosed no relevant financial relationships.
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